Mob ntsej rag, Muaj tej lub caij zoo li no: "Muaj tej lub caij uas yus ua taukua txiv ntseg”, tus kab mob bacterial feem ntau yog cov kab mob bacterial kab mob hauv Menyuam thiab los ntawm 1 lub xyoo uas muaj hnub nyoog txog 60% cov me nyuam yuav tau txhaj ib. Tej zaum, me nyuam yaus mob chronic mob, uas, dua li ntawm cov raug tus mob no yog kho, tus “kua nplaum” tsis txhob tseg thiab ua rau muaj lag ntseg. Pub rau ib qho pub nas tsuag qauv Chronic glue pob ntseg lub causative mutation muaj tau pom tias yuav tsum tau nyob rau hauv ib lub noob encoding ib ntaus tej yam zoo li cas, Evi1.
Tus EVI1 protein ntau muaj ntau domains, yuav repress los yog txhim khu kev qha ntawm lub hom phaj thiab sib tham nrog ntau lwm proteins. Xwb, Cov multiplicity paub thiab tej kev sib tshuam yog ib tug sib tw los txiav txim rau lub luag hauj lwm ntawm cov mutation. There were clues, Txawm li cas los, Yuav ua li cas no mutation yuav ua rau muaj mob los ntawm qhov txawv hauv phenotype e.g. mutant nas tsa ceg nyob rau hauv ib "huv" SPF tsiaj muaj tsawg yuav ua lag ntseg dua cov cia nyob rau hauv cov laus, "tsiaj txhu".
Qhov no txhais tau tias noob kev sib tshuam e.g. lub nruab nrog cev tsis muaj zog thiab microbes, cawv? Nws twb tseem paub tias mutant nas tsom theem ntawm influx ntawm neutrophils rau hauv lawv nruab nrab pob ntseg cavities (mob), Tiam sis yog paub tsis meej seb EVI1 yog kuj ncaj qha los yog indirectly nyob rau hauv txoj kev no. Tau cov lus teb rau cov lus nug no los tsis ntev los no los ntawm kev tshawb fawb hauv cultured hlwb, uas qhia EVI1 ua tau ib qho kev ua tau zoo hais txog Yog ib qhov tseem ceeb proteins regulating inflammation, Lwm transcription factor, nuclear factor kappa B (NFKB). EVI1 binds rau ib lub subunits ntawm NFkB thiab cuam tshuam nrog ib protein tseem ceeb heev modification, acetylation. tiam sis, EVI1 tsis acetylate proteins ncaj qha mus ncaj qha, Li ntawd, lwm yam yuav tsum muab kev koom tes. Cov no yog cov uas muaj cov lwm yam?
Kuv tag nrho pej xeem thiab unpublished cov ntaub ntawv siv tshawb fawb thiab qhov chaw software e.g. iRefWeb Thiaj li yuav qhia tau cov kauj ruam hauv lub NFkB signalling pathways uas tej zaum yuav tau disturbed los ntawm cov mutation hauv EVI1. Tus tshiab Phiaj proteins thiab pib ntsiab lus rau kev loj hlob Kuv sab yog suitable rau kev kuaj no qauv preclinical qauv mob ntsws mob.
Nyeem peb cov lus los ntawm Dr Michael Cheeseman.
