Chaw tsom xam cov ntaub ntawv qhia noob – txiv neej txo fertility / sterility

Ib pawg tsiaj uas yuav nteg qe thiab ua fertile offspring yog ib lub ntsiab txhais ntawm ib hom.

Qhov no txhais tau tias cov mechanisms biological mechanisms ntawm fertility thiab infertility yog txaus siab tsis zoo xwb evolutionary biologists, Tiam sis kuj mus clinicians thiab tiv thaiv rau pej xeem wider. Ntawm lub koom haum ntawm Molecular Genetics hauv Prague, Prof. Jiri Forejt yog kawm dab tsi controls fertility hauv lub hybrid offspring uas ua los ntawm tus mating ntawm mouse sub-hom. Nws xav paub vim li cas ib txhia txiv neej nas tau infertile – nws paub tias noob nyob rau hauv ib qho genome thaj av ntawd tseem ceeb heev, Tab sis tsis li cas cov noob cawv cov qhia txog tas cov genome.

Qhov no yog qhov twg kuv yog recruited rau hauv pab neeg no, Pab kom paub cov hoob kawm ntawm noob cuam tshuam kev thauj hauv nas tsuag uas txo fertility. Zaum hauv nws pab pawg neeg tau ua Affymetrix noob qhia tau los ntawm qhov kev kuaj ntawd fertile, sub-fertile thiab infertile nas thiab kuv analysed cov ntaub ntawv genome-dav rau txawv-expressed transcripts. Siv lub koom haum Broad lub koom haum marvellous GSEA cuab yeej, Kuv ntsuam xyuas cov pov thawj txheeb cais tias specific Gene Ontology cov ntsiab lus thiab pathways tau over-uas muaj tuaj thiab kuj seb txawv noob tau localised los particular genome regions. No tsom xam uncovered pov thawj tias specific, Functionally hais txog cov noob tau over-uas muaj tuaj hauv cov ntaub ntawv qhia thiab pab tsim tshiab hypotheses txog qhov uas txo fertility.