hawb pob tshwm sim los ntawm thaum lawv tseem ua ke ib puag ncig thiab noob caj noob ces cawv, tab sis, rau tej yam yuav tsis to taub. Ib qhov "ntaus" kuaj tau nyob rau hauv ib cov koom haum genome-dav scan (GWAS) rau cov me nyuam yaus hawb pob coj ib tug neeg tau ntseeg tias ib tug noob tej zaum yuav feem ntau lub luag hauj lwm. Tseeb tiag tias no cov koom haum caj yeej yog ua rau mob hawb pob heev, Txawm li cas los, nyuaj. Firstly, Tsis muaj leej twg paub lub function ntawm cov protein ntau los ntawm lub noob thiab secondly, hloov noob rau tib neeg mus kuaj ib hypothesis, es raws li txoj kev kho, kev nyuaj siab & ethically questionable, tshwj xeeb tshaj yog rau cov me nyuam yaus. qhov zoo ces, nas tsuag sib koom txog 90% Lawv noob nrog tib neeg, Li ntawd, zaum "knocked-out" cov noob sib npaug, Ces kuaj seb cov tsiaj no coj zoo ib yam li cov me nyuam hawb pob. Cov lus teb luv yog – lawv tsis. nyob rau hauv ntsws Kev ntsuam xyuas uas yuav muaj asthmatics xeeb rau lawv inhalers, tus knock-out nas tsuag kiag li dab tsi. Li ntawd, Dab tsi yog yuav mus? Nas tsuag tsis txaus nyiam tib neeg? Yog qhov no tsis ncaj ncees lawm?
Rau qhov project no, Kuv rov qab mus ua ntej txhooj – dab tsi yog qhov pov thawj Txhawb lub tswv yim tias lub noob no yog lub luag hauj lwm rau hawb pob? Digging los ntawm qhov hauv internet ntawv nyeem, Particular ntaub ntawv los ntawm lwm pawg kawm tib yam noob muab tau khoom siv tsis muaj nyob rau hauv cov ntawv luam, Muaj tswv yim tias cov noob caj noob ces muaj ntau txoj. Kuv nrhiav tau pov thawj tias ob tug lwm noob Nyob ze tau xws li ntau los yog tsawg transcriptionally active asthmatics thiab ces tej zaum yuav ua si ua kom mob hawb pob. Tas, siv cov ntaub ntawv los ntawm ENCODE ib tes num, Kuv nrhiav tau tias lub caij ntxawg predicted los tswj cov noob no yog conserved hauv nas, Li ntawd, nws yuav tau mus kuaj txoj hau kev yuav xyaum ua tej yam.
Qhov no pom tias ib tug tshiab tshuaj – altering tej yam uas yuav ua tau cluster ntawm noob, es yog ib tug xwb, tej zaum yuav hloov kab mob.
