Gene Set Enrichment Analysis is one of many approaches to the analysis of gene expression profile data and is described in a paper from workers at the Broad Institute. The basic concept was prompted by the observation that studying individual genes showing the most significant difference in expression level between two states or phenotypes is lacking [...]
Author Archives: Paul Denny
Pathway Analizo uzanta la Genan Aran #Ri?igo Analizon (GSEA) Ilo
#Po?ti en Pathway analizo
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Joys of editing academic science books
Or: “A beginner’s guide to herding cats”. Consider this scenario: you are an academic scientist, in a busy research institute and your boss is invited to edit a book, but declines due to pressure of work; then suggests that it would look good on your CV. You agree, it would look good on your CV, so [...]
#Po?ti en Luma #trankvili?o
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Kiel faras mutacion en transskriba faktora afera gluo orelo?
Acute otitis media, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 year of age about 60% of children will have had one episode. In some cases, children develop a chronic condition, which, despite the infection being cured, La “glue” doesn’t go away and causes deafness. In an [...]
#Po?ti en Pathway analizo, Cela eltrovo
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Cela eltrovo en #infana?o-ekkomenca astmo
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, Tamen, difficult. Unue, [...]
#Po?ti en Cela eltrovo
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Pathway analizo de gena esprimo datumo – Viro reduktis fekundecon / Sterileco
Grupo de bestoj kiu povas bredi kaj produkti fekundan idon estas unu el la difinoj de specio. #Tio ?i signifas ke la biologiaj mekanismoj de fekundeco kaj malfekundeco estas de intereso ne nur al evoluaj biologoj, Sed #anka? al klinikistoj kaj nature al la pli #lar?a publiko. At the Institute of Molecular Genetics in [...]
#Po?ti en Pathway analizo, Cela eltrovo
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Cela eltrovo en heredita muskolan malforton
Muskola malforto povas esti #ka?zi de malofta heredita malsanon vokis myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Ilia celo estis eltrovi potencialajn terapiajn celojn traduki en pre-klinikaj kaj klinikaj studoj. #Anta? ol mi #fari?i okupita, the disease had [...]
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