Genes are not passive. They are the target of molecular “dimmer switches”; typically (but not always) specific proteins, which dial up or turn down their activity. Most genes are translated into proteins, but discovering the true role of those proteins, in the life of a cell or a whole organism, is still one of the great challenges [...]
Categoría: Target descubrimiento
¿Cómo funciona una mutación en un factor de transcripción oído pegamento causa?
Acute otitis media, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 year of age about 60% of children will have had one episode. In some cases, children develop a chronic condition, which, despite the infection being cured, the “glue” doesn’t go away and causes deafness. In an [...]
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Target descubrimiento en el asma durante la infancia
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, however, difficult. Firstly, [...]
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Pathway análisis de datos de expresión génica – reduce la fertilidad masculina / esterilidad
Un grupo de animales que pueden reproducirse y producir descendencia fértil es una de las definiciones de una especie. Esto significa que los mecanismos biológicos de la fertilidad y la infertilidad son de interés no sólo para los biólogos evolutivos, sino también para los médicos y por supuesto al público en general. At the Institute of Molecular Genetics in [...]
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Target descubrimiento en la debilidad muscular hereditario
Muscle weakness can be caused by a rare inherited disease called myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Their aim was to discover potential therapeutic targets to translate into pre-clinical and clinical studies. Before I became involved, the disease had [...]
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