Gene Set Enrichment Analysis is one of many approaches to the analysis of gene expression profile data and is described in a paper from workers at the Broad Institute. The basic concept was prompted by the observation that studying individual genes showing the most significant difference in expression level between two states or phenotypes is lacking [...]
Author Archives: پل دنی
تجزیه و تحلیل مسیر با استفاده از تجزیه و تحلیل ژن تنظیم غنی سازی (GSEA) ابزار
موضوع: تجزیه و تحلیل مسیر
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Joys of editing academic science books
Or: “A beginner’s guide to herding cats”. Consider this scenario: you are an academic scientist, in a busy research institute and your boss is invited to edit a book, but declines due to pressure of work; then suggests that it would look good on your CV. You agree, it would look good on your CV, so [...]
موضوع: کمک های نور
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چگونه یک جهش در فاکتور رونویسی علت گوش چسب?
Acute otitis media, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 year of age about 60% of children will have had one episode. In some cases, children develop a chronic condition, which, despite the infection being cured, the “glue” doesn’t go away and causes deafness. In an [...]
موضوع: تجزیه و تحلیل مسیر, کشف مقصد
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کشف هدف در آسم دوران کودکی شروع
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, however, difficult. Firstly, [...]
موضوع: کشف مقصد
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تجزیه و تحلیل مسیر داده های بیان ژن – مرد کاهش باروری / عقیمی
گروهی از حیوانات است که می تواند به پرورش و تولید فرزندان بارور یکی از تعاریف از یک گونه است. این به این معنی است که مکانیسم های بیولوژیکی باروری و ناباروری مورد علاقه نه تنها به زیست شناسان تکاملی هستند, بلکه به پزشکان و البته به عموم مردم گسترده تر. At the Institute of Molecular Genetics in [...]
موضوع: تجزیه و تحلیل مسیر, کشف مقصد
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کشف هدف در ضعف عضلانی به ارث برده
Muscle weakness can be caused by a rare inherited disease called myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Their aim was to discover potential therapeutic targets to translate into pre-clinical and clinical studies. Before I became involved, the disease had [...]
موضوع: کشف مقصد
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