Genes are not passive. They are the target of molecular “dimmer switches”; typically (but not always) specific proteins, which dial up or turn down their activity. Most genes are translated into proteins, but discovering the true role of those proteins, in the life of a cell or a whole organism, is still one of the great challenges [...]
بايگاني موضوعات: کشف مقصد
چگونه یک جهش در فاکتور رونویسی علت گوش چسب?
Acute otitis media, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 year of age about 60% of children will have had one episode. In some cases, children develop a chronic condition, which, despite the infection being cured, the “glue” doesn’t go away and causes deafness. In an [...]
و نيز: تجزیه و تحلیل مسیر
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کشف هدف در آسم دوران کودکی شروع
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, however, difficult. Firstly, [...]
موضوع: کشف مقصد
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تجزیه و تحلیل مسیر داده های بیان ژن – مرد کاهش باروری / عقیمی
گروهی از حیوانات است که می تواند به پرورش و تولید فرزندان بارور یکی از تعاریف از یک گونه است. این به این معنی است که مکانیسم های بیولوژیکی باروری و ناباروری مورد علاقه نه تنها به زیست شناسان تکاملی هستند, بلکه به پزشکان و البته به عموم مردم گسترده تر. At the Institute of Molecular Genetics in [...]
و نيز: تجزیه و تحلیل مسیر
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کشف هدف در ضعف عضلانی به ارث برده
Muscle weakness can be caused by a rare inherited disease called myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Their aim was to discover potential therapeutic targets to translate into pre-clinical and clinical studies. Before I became involved, the disease had [...]
موضوع: کشف مقصد
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