Genes are not passive. They are the target of molecular “dimmer switches”; typically (but not always) specific proteins, which dial up or turn down their activity. Most genes are translated into proteins, but discovering the true role of those proteins, in the life of a cell or a whole organism, is still one of the great challenges [...]
Архив категории Целевая открытие
Как мутации в причинно транскрипции уха клей фактор?
Acute otitis media, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 year of age about 60% of children will have had one episode. In some cases, children develop a chronic condition, which, despite the infection being cured, the “glue” doesn’t go away and causes deafness. In an [...]
Также опубликована в Путь анализа
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Target discovery in childhood-onset asthma
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, however, difficult. Во-первых, [...]
Опубликовано в рубрике Целевая открытие
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Путь анализа данных экспрессии генов – мужской снижение рождаемости / бесплодие
A group of animals that can breed and produce fertile offspring is one of the definitions of a species. This means that the biological mechanisms of fertility and infertility are of interest not only to evolutionary biologists, but also to clinicians and of course to the wider public. At the Institute of Molecular Genetics in [...]
Также опубликована в Путь анализа
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Целевая открытие в унаследованной слабости мышц
Мышечная слабость может быть вызвана редкое наследственное заболевание, называемое миофибриллярных миопатии. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Их целью было обнаружить потенциальные терапевтические мишени перевести на доклинических и клинических исследований. Прежде чем я стал участвовать, the disease had [...]
Опубликовано в рубрике Целевая открытие
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