Gene Set Enrichment Analysis is one of many approaches to the analysis of gene expression profile data and is described in a paper from workers at the Broad Institute. The basic concept was prompted by the observation that studying individual genes showing the most significant difference in expression level between two states or phenotypes is lacking [...]
Author Archives: Paul Denny
Pathway Analysis using the Gene Set Enrichment Analysis (GSEA) Tool
Posted in Pathway na pagsusuri
1 Response
Joys of editing academic science books
Or: “A beginner’s guide to herding cats”. Consider this scenario: you are an academic scientist, in a busy research institute and your boss is invited to edit a book, but declines due to pressure of work; then suggests that it would look good on your CV. You agree, it would look good on your CV, so [...]
Posted in Banayad na lunas
1 Response
Paano gumagana ang isang pagbago sa isang transcription tainga factor dahilan kola?
Acute otitis media, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 year of age about 60% of children will have had one episode. In some cases, children develop a chronic condition, which, despite the infection being cured, the “glue” doesn’t go away and causes deafness. In an [...]
Target discovery in childhood-onset asthma
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, however, difficult. Una, [...]
Posted in Target na pagtuklas
Leave a comment
Pathway na pagtatasa ng data ng gene expression – lalaki nabawasan pagkamayabong / baog
A group of animals that can breed and produce fertile offspring is one of the definitions of a species. This means that the biological mechanisms of fertility and infertility are of interest not only to evolutionary biologists, but also to clinicians and of course to the wider public. At the Institute of Molecular Genetics in [...]
Posted in Pathway na pagsusuri, Target na pagtuklas
1 Response
Target pagtuklas sa minana kalamnan kahinaan
Kalamnan kahinaan ay maaaring sanhi ng isang bihirang minana sakit na tinatawag na myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Ang kanilang layunin ay upang matuklasan ang mga potensyal na nakakagaling na mga target upang i-translate sa pre-klinikal at clinical mga pag-aaral. Bago ako ay naging kasangkot, the disease had [...]
Posted in Target na pagtuklas
Leave a comment
