Genes are not passive. They are the target of molecular “dimmer switches”; typically (but not always) specific proteins, which dial up or turn down their activity. Most genes are translated into proteins, but discovering the true role of those proteins, in the life of a cell or a whole organism, is still one of the great challenges [...]
Category Archives: Target na pagtuklas
Paano gumagana ang isang pagbago sa isang transcription tainga factor dahilan kola?
Acute otitis media, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 year of age about 60% of children will have had one episode. In some cases, children develop a chronic condition, which, despite the infection being cured, the “glue” doesn’t go away and causes deafness. In an [...]
Also posted in Pathway na pagsusuri
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Target discovery in childhood-onset asthma
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, however, difficult. Una, [...]
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Pathway na pagtatasa ng data ng gene expression – lalaki nabawasan pagkamayabong / baog
A group of animals that can breed and produce fertile offspring is one of the definitions of a species. This means that the biological mechanisms of fertility and infertility are of interest not only to evolutionary biologists, but also to clinicians and of course to the wider public. At the Institute of Molecular Genetics in [...]
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Target pagtuklas sa minana kalamnan kahinaan
Kalamnan kahinaan ay maaaring sanhi ng isang bihirang minana sakit na tinatawag na myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Ang kanilang layunin ay upang matuklasan ang mga potensyal na nakakagaling na mga target upang i-translate sa pre-klinikal at clinical mga pag-aaral. Bago ako ay naging kasangkot, the disease had [...]
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