Genes are not passive. They are the target of molecular “dimmer switches”; typically (but not always) specific proteins, which dial up or turn down their activity. Most genes are translated into proteins, but discovering the true role of those proteins, in the life of a cell or a whole organism, is still one of the great challenges [...]
Category Archives: 目標發現
如何定義一個轉錄因子引起膠耳中的突變?
急性化膿性中耳炎, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 年樹齡約 60% 孩子都會有一個情節. 在某些情況下, children develop a chronic condition, 哪, 儘管被治愈的感染, 在 “膠水” doesn’t go away and causes deafness. In an [...]
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目標發現在兒童期發病的哮喘
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, 然而, difficult. Firstly, [...]
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基因表達數據的途徑分析 – 男性生育能力下降 / 不育症
A group of animals that can breed and produce fertile offspring is one of the definitions of a species. This means that the biological mechanisms of fertility and infertility are of interest not only to evolutionary biologists, but also to clinicians and of course to the wider public. At the Institute of Molecular Genetics in [...]
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的目標發現在遺傳性肌肉無力
Muscle weakness can be caused by a rare inherited disease called myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Their aim was to discover potential therapeutic targets to translate into pre-clinical and clinical studies. Before I became involved, the disease had [...]
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