Genes are not passive. They are the target of molecular “dimmer switches”; typically (but not always) specific proteins, which dial up or turn down their activity. Most genes are translated into proteins, but discovering the true role of those proteins, in the life of a cell or a whole organism, is still one of the great challenges [...]
Archiwum Kategorii: Cel odkrycie
Jak mutację w uchu przyczyny czynnika transkrypcyjnego kleju?
Ostre zapalenie ucha środkowego, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 roku życia o 60% dzieci będą miały jeden epizod. W niektórych przypadkach, children develop a chronic condition, który, mimo zakażenia wyleczenie, the “klej” doesn’t go away and causes deafness. In an [...]
Opublikowano również w Analiza Pathway
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Odkrycie docelowa w wystąpił w dzieciństwie astmy
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, jednak, difficult. Firstly, [...]
Opublikowano w Cel odkrycie
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Analiza Pathway danych ekspresji genów – zmniejszenie płodności mężczyzn / bezpłodność
A group of animals that can breed and produce fertile offspring is one of the definitions of a species. This means that the biological mechanisms of fertility and infertility are of interest not only to evolutionary biologists, but also to clinicians and of course to the wider public. At the Institute of Molecular Genetics in [...]
Opublikowano również w Analiza Pathway
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Odkrycie docelowa w odziedziczonej słabości mięśni
Muscle weakness can be caused by a rare inherited disease called myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Their aim was to discover potential therapeutic targets to translate into pre-clinical and clinical studies. Before I became involved, the disease had [...]
Opublikowano w Cel odkrycie
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