Gene Set Enrichment Analysis is one of many approaches to the analysis of gene expression profile data and is described in a paper from workers at the Broad Institute. The basic concept was prompted by the observation that studying individual genes showing the most significant difference in expression level between two states or phenotypes is lacking [...]
Author Archives: Paul Denny
Analiza przy użyciu zestawu Pathway Gene Analiza Enrichment (GSEA) Narzędzie
Opublikowano w Analiza Pathway
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Radości edycji książki naukowe akademickie
Or: “A beginner’s guide to herding cats”. Consider this scenario: you are an academic scientist, in a busy research institute and your boss is invited to edit a book, but declines due to pressure of work; then suggests that it would look good on your CV. You agree, it would look good on your CV, so [...]
Opublikowano w Lekka ulga
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Jak mutację w uchu przyczyny czynnika transkrypcyjnego kleju?
Ostre zapalenie ucha środkowego, sometimes known as “glue ear”, is the most common bacterial infection in children and by 1 roku życia o 60% dzieci będą miały jeden epizod. W niektórych przypadkach, children develop a chronic condition, który, mimo zakażenia wyleczenie, the “klej” doesn’t go away and causes deafness. In an [...]
Opublikowano w Analiza Pathway, Cel odkrycie
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Odkrycie docelowa w wystąpił w dzieciństwie astmy
Asthma is caused by a combination of environmental and genetic influences, but the specific factors are poorly understood. A significant “hit” detected in a genome-wide association scan (GWAS) for childhood asthma led a client to believe that one gene might be partially responsible. Proving that this genetic association really was causing asthma was, jednak, difficult. Firstly, [...]
Opublikowano w Cel odkrycie
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Analiza Pathway danych ekspresji genów – zmniejszenie płodności mężczyzn / bezpłodność
A group of animals that can breed and produce fertile offspring is one of the definitions of a species. This means that the biological mechanisms of fertility and infertility are of interest not only to evolutionary biologists, but also to clinicians and of course to the wider public. At the Institute of Molecular Genetics in [...]
Opublikowano w Analiza Pathway, Cel odkrycie
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Odkrycie docelowa w odziedziczonej słabości mięśni
Muscle weakness can be caused by a rare inherited disease called myofibrillar myopathy. Gonzalo Blanco’s team found a mouse model of this disease and wanted to identify the underlying cause of the severe muscle weakness. Their aim was to discover potential therapeutic targets to translate into pre-clinical and clinical studies. Before I became involved, the disease had [...]
Opublikowano w Cel odkrycie
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